Berlin-Brandenburg dominates Europe’s rank list of medical technology regions, with around 350 companies employing nearly 14,700 people. The region generates annual revenues of €1.5 billion. While many of these companies are small to medium-sized enterprises (SMEs), their impact is far-reaching, with a reputation for delivering cutting-edge products in telemedicine, eHealth, medical imaging, oncology, and cardiology. Berlin-Brandenburg has long been a global player in medical innovations, and a hotbed for advancements in medical equipment. The medical equipment produced in Berlin-Brandenburg is not only vital for local healthcare but is also highly successful in international markets. Several companies in the region are recognized as leaders in their respective fields. For instance, Berlin Heart is known for its external pumps for infants with cardiac conditions, while Biotronik manufactures advanced pacemakers. The field of minimally invasive medicine also shines in Berlin-Brandenburg, where companies such as W.O.M. World of Medicine, MGB Endoskopische Geräte Berlin, and XION develop some of the world’s best endoscopes, insufflators, and camera systems. Innovations in orthopaedics and implants come from firms like aap Implantate, Merete Medical, and ZIMMER Biomet Deutschland, which provide solutions that cater to the increasing global demand for advanced medical devices. Berlin-Brandenburg stands out for its efficient technology transfer from research to market-ready products. Collaboration between hospitals, research institutions, and industry players facilitates the rapid development of competitive innovations. More than 140 hospitals in the region, along with prestigious institutions like Charité, the Berlin Institute of Health (BIH), and the German Heart Center Berlin, ensure an environment where new medical technologies can be tested, refined, and brought to market efficiently. The presence of over 40 scientific institutions, including the Fraunhofer Institute for Biomedical Engineering IBMT, and others from the Helmholtz, Leibniz, and Max Planck networks, supports a thriving ecosystem for medical research and development.